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Last Updated: 3 months ago

Possible Interaction: Adenosine and Cinepazide

supplement:

Adenosine

Research Papers that Mention the Interaction

Cinepazide in concentrations ranging from 10(-6) to 10(-5) M augmented the relaxing responses to ATP, adenosine and cAMP.
Pharmacology  •  1984  |  View Paper
Cinepazide (3 X 10(-4) M) retarded the degradation of adenosine , and the formation of inosine and hypoxanthine.
The negative inotropic effects of adenosine and adenine nucleotides, such as ATP and cAMP, on guinea-pig atria were selectively and dose-dependently augmented by cinepazide in concentrations insufficient to produce any effect alone (3 X 10(-5) M-3 X 10(-4)M).
These results suggest that cinepazide potentiates the negative inotropic effect of adenosine on guinea-pig atria by preventing both its degradation by deaminase and its accumulation by atrial tissue.
Archives internationales de pharmacodynamie et de therapie  •  1980  |  View Paper