Possible Interaction: Adenosine and Central Nervous System Stimulants

“The observation that adenosine can either inhibit or stimulate adenylate cyclase had just led to the C. E. Müller (*) :A. C. Schiedel PharmaCenter Bonn, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany e-mail: christa.mueller@uni-bonn.de”

“PGD2 stimulates DP1 receptors localized in the basal forebrain and increases the local extracellular concentration of adenosine , a paracrine signaling molecule, to promote sleep.”

“PGD2 stimulates DP, receptors localized in the basal forebrain and increases the local extracellular concentration of adenosine , which activates A2A receptor-possessing neurons in the basal forebrain and/or ventrolateral preoptic area (VLPO).”

“Moreover, adenosine tonically inhibits the renal release of renin and stimulates NaCl transport in the cortical proximal tubule but inhibits it in medullary segments including the medullary thick ascending limb.”

“Overall, our observations suggest that adenosine might modulate tissue remodeling by stimulating fibronectin expression in lung epithelial cells through induction of purinergic receptor-mediated signals that target CREB phosphorylation and stimulate fibronectin gene transcription.”

“This provides a switch mechanism by which low and high concentrations of adenosine inhibit and stimulate , respectively, glutamate release.”

“We have recently demonstrated that adenosine inhibits tumour cell growth and concomitantly stimulates bone marrow cell proliferation via activation of the A3 adenosine receptor (A3AR).”

“In ODM Clone-2, a cell line derived from human nonpigmented ciliary epithelium (… a clone derived from bovine pigmented ciliary epithelium (PE), we observed that adenosine inhibits adenylate cyclase activity … potency (nM) and stimulates adenylate cyclase activity at low potency (microM) suggesting … of P1 subtypes on these cell membranes.”

“Indeed, adenosine increases Na ⁄ I symporter gene expression and stimulates I-transport via the A1 adenosine receptor–Gi ⁄ Go protein signal transduction pathway in FRTL-5 cells.”

“ Adenosine inhibits the cell‐mediated anti‐tumor immune response, promotes tumor cell migration and angiogenesis, and stimulates the proliferation of tumor cells.”