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“OBJECTIVE The mood stabilizing drugs lithium, carbamazepine and valproate modulate brain adenosine monophosphate (cAMP) levels, which are assumed to be elevated in bipolar disorder patients.”
“Thus, CBZ treatment for 10 days induces a new quality of adenosine A1-receptor-mediated signal transduction in cells that express low basal A1-receptor numbers.”
“ Carbamazepine failed to potentiate the actions of iontophoretically applied adenosine on cerebral cortical neurons, and at higher doses it reduced the duration of adenosine‐elicited depressions.”