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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Adenosine
Research Papers that Mention the Interaction
“… adenosine (… hCGRP at concentrations of 3 X 10(-9) and 3 X 10(-8) M, but not at that of 3 X 10(-7) M. Ouabain (… pretreatment with verapamil (10(-5) M) and ouabain (5 X 10(-5) M) suppressed the positive inotropy by hCGRP at all concentrations tested.”
Possible mechanisms of positive inotropic action of synthetic human calcitonin gene-related peptide in isolated rat atrium“ CGRP increased ATP and ADP levels in meninges and trigeminal cultures and reduced adenosine concentration in trigeminal cells.”
Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions“The protein kinase‐A inhibitors, N‐(2‐guanidinoethyl)‐5‐isoquinolinesulfonamide (HA‐1004, 10 μM) and adenosine 3′,5′‐cyclic monophosphorothioate, Rp‐isomer (Rp‐cAMPS, … (10 nM), suggesting that this effect of CGRP involves both KATP channels and protein kinase‐A. It is concluded that the ability of CGRP … adenosine, ….”
“The positive inotropic response to CGRP was significantly enhanced by isobutylmethylxanthine and was attenuated by adenosine.”
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