Possible Interaction: Adenosine and Caffeine

“ Adenosine is a neuromodulator with mostly inhibitory activity that is released by physiological stimuli and can be blocked by non-selective adenosine receptor antagonists such as theophylline and caffeine.”

“It is believed that caffeine attenuates the coronary hyperemic response to adenosine by blocking the A2a receptors.”

“These data are in accordance with the hypothesis that adenosine is a mediator of performance decrements associated with extended wakefulness and may lead to new strategies to use caffeine in situations in which neurobehavioral functioning is affected by sleep loss.”

“At physiological doses, caffeine acts as a competitive antagonist to the inhibitory effects of adenosine.”

“Patients scheduled for (201)Tl myocardial perfusion using pharmacologic stress with dipyridamole or adenosine are advised to abstain from caffeine for 24 h before the test.”

“These data support our hypothesis that caffeine ingestion decreases glucose disposal and suggests that adenosine plays a role in regulating glucose disposal in resting humans.”

“In addition, caffeine , but not enprofylline, reduced the cardiovascular response to exogenous adenosine.”

“This response to adenosine was reduced by pretreatment with caffeine but not enprofylline.”

“Our results indicate an antagonism between caffeine and adenosine in humans, which may support the suggestion that some circulatory effects of caffeine are caused by an interaction with endogenous adenosine.”

“Our results suggest that adenosine stimulates respiration in man by binding with specific P1-purinoceptors, which can be blocked by caffeine , but not by enprofylline.”

“Hence, caffeine increases glomerular filtration rate by opposing the vasoconstriction of renal afferent arteriole mediated by adenosine via type 1 AR during the tubuloglomerular feedback.”