Possible Interaction: Adenosine and Bradykinin

“In many models, adenosine plays a role by triggering the activation of protein kinase C. It may work in conjunction with other agents, such as bradykinin , but the putative role of noradrenaline is uncertain.”

“In conclusion, the data show that muscular activity increases the interstitial concentrations of bradykinin and adenosine in both skeletal muscle and the connective tissue around its adjacent tendon.”

“7 In conclusion, afferent discharge induced by BK is augmented by histamine, adenosine and PGE2, but not by 5‐HT.”

“When adenosine or N6-cyclopentyladenosine was combined with bradykinin , the resulting formation of inositol 1,4,5-triphosphate was more than additive, and the EC50 value for adenosine and N6-cyclopentyladenosine was shifted to the left by bradykinin, the affinity of which was unaltered.”

“The results suggest that adenosine potentiates bradykinin-induced plasma exudation via an adenosine receptor and that histamine may be involved to some extent in the phenomenon.”

“However, evidence suggests that adenosine , released during the initial ischemic insult, activates a variety of G protein-coupled agonists, such as opioids, bradykinin , and catecholamines, resulting in the activation of protein kinases, especially protein kinase C (PKC).”

“Pretreatment of atrial myocytes with phenylephrine, endothelin-1, or bradykinin prior to a second application of Ado reduced the amplitude of the second I(K(Ado)) to 25.5+/-11.6%, 30.5+/-5.6%, and 96.0+/-2.7%, respectively.”