Possible Interaction: Adenosine and Atropine

“With dipyridamole [5], dobutamine [6] and adenosine [7], the sensitivity increases with higher doses and with atropine co-administration.”

“ Adenosine significantly lengthened the sinus cycle length in the baseline state (760 ± 165 vs 909 ± 188 ms, P < 0.05), during isoproterenol infusion (…, P < 0.05), after propranolol (850 ± 153 vs 914 ± 143 ms, P < 0.05) and after the combination of propranolol and atropine (662 ± 76 … < 0.05).”

“In both groups 3 and 4, the minimal dose of adenosine required to terminate tachycardia during atropine injection with 0.02 mg/kg was greater than that during the baseline state.”

“The inhibition of AMP‐ and CPA‐induced airway obstruction by atropine , capsaicin and bilateral vagotomy suggests a neuronal‐dependent mechanism with the particular involvement of capsaicin‐sensitive nerves.”

“ Adenosine induces a dose-dependent stimulation on amylase release, which is maximal at a concentration of 10(-4) M. It has been observed a clear inhibition of this secretory action when atropine was added whereas no amylase release was seen in isolated acini after adenosine.”

“In the oesophagus, adenosine , AMP, ADP and ATP (above 10 microM) and acetylcholine (above 1 nM) caused concentration-dependent contractions that were antagonised by atropine (1 microM).”

“The bronchoconstriction caused by adenosine is inhibited by atropine , methysergide, sodium cromoglycate, nedocromil sodium, and ketotifen.”

“In the rat vas deferens the rate of resensitization of responses to NA was retarded by adenosine and this effect was abolished by 8-phenyltheophylline and by yohimbine, but not by atropine or propranolol.”

“ Atropine (0.2 mg/kg) significantly attenuated the electrophysiologic effects of 2.90 microM/kg Stridyne and ATP but not those of adenosine.”

“Adenosine (3.0 mg/kg) reduced the contractions by 47 +/- 4% (n = 14); in guinea-pigs pretreated with atropine (10 mg/kg), adenosine produced a further 10 to 20% decrease of the responses.”