Possible Interaction: Adenosine and Aspartate

“By inhibiting neuronal Ca2+ influx, adenosine counteracts the presynaptic release of the potentially excitotoxic neurotransmitters glutamate and aspartate , which may impair intracellular Ca2+ homeostasis via metabotrophic glutamate receptors or induce uncontrolled membrane depolarization via ion channel-linked glutamate receptors, especially of the N-methyl-D-aspartate (NMDA) type.”

“In chicken liver homogenate gluconeogenesis from precursors such as alanine, glutamate, glutamine and aspartate , which are not converted into glucose by the perfused chicken liver, proceeded at rates equal to or higher than that with lactate, being markedly inhibited by Ado.”

“Abstract: In rat hippocampal synaptosomes, adenosine decreased the K+ (15 mM) or the kainate (1 mM) evoked release of glutamate and aspartate.”

“Superfusion with glucose-deficient medium abolished the inhibitory effect of adenosine on glutamate and aspartate release , but augmented the enhancing effect of the adenosine antagonist 8-phenyltheophylline.”

“ Adenosine reduced the K+‐evoked release of glutamate and aspartate by a maximum of about 60%, but did not affect the release of GABA.”

“ Adenosine , at 3 X 10(-4) M concentration, inhibited the stimulation-evoked potentials and prevented the stimulation-induced release of aspartate and glutamate.”

“Mutual potentiation of effects was observed when aspartate was added together with either adenosine or histamine, but not with glutamate, veratridine, or ouabain.”

“In the presence of adenosine , the conversion of labelled aspartate to uridine nucleotides was reduced by 80-85%, and labelled orotate accumulated in both the cells and in the culture medium.”