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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Adenosine
Research Papers that Mention the Interaction
“Endogenous adenosine systems contribute to antinociceptive properties of caffeine, opioids, noradrenaline, 5-hydroxytryptamine, tricyclic antidepressants and transcutaneous electrical nerve stimulation.”
Adenosine receptor activation and nociception.“These observations also suggest that agents that increase brain adenosine levels may have antidepressant efficacy.”
“It is suggested that the blockade of the cellular uptake of adenosine , or indirect enhancement of its release, and subsequent activation of adenosine A1 receptors may be responsible for the inhibitory effect of antidepressants on Glu and Asp release.”
Involvement of adenosine in the effect of antidepressants on glutamate and aspartate release in the rat prefrontal cortex“5 Earlier studies showed the tricyclic antidepressants inhibit the uptake of adenosine by rat brain cerebral cortical synaptosomes.”
“The present results demonstrate that four antidepressants are able to potentiate the action of adenosine and that this occurs when these compounds are given in behaviourally meaningful doses.”
“The results have demonstrated a CPT-induced enhancement of the antidepressant-like effect of imipramine both in the FST and TST, which may indicate that the adenosine system may be involved in the increasing the effect of antidepressant.”
8-Cyclopentyl-1,3-dimethylxanthine enhances effectiveness of antidepressant in behavioral tests and modulates redox balance in the cerebral cortex of mice
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