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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Anticonvulsants
Research Papers that Mention the Interaction
“ Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties.”
Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish.“Although the role of adenosine is rather uncontroversial, the origin of the adenosine mediating this anticonvulsant effect has been somewhat contentious.”
“Therefore, we concluded that part of anticonvulsant effect of valerian probably is mediated through activation of adenosine system.”
“Endogenous adenosine in the brain is thought to prevent the development and spread of seizures via a tonic anticonvulsant effect.”
“ Adenosine , an endogenous inhibitory neuromodulator in the central nervous system, exerts anticonvulsant activity that is largely based on the inhibition of the release of excitatory amino acids.”
“A number of groups of centrally active sedative, anxiolytic and anticonvulsant drugs inhibit adenosine uptake by brain synaptosomal preparations.”
“Exogenously applied adenosine appeared to have anticonvulsant properties (EC50∼ 10 μM), in that it slowed or suppressed spontaneous interictal discharges.”
“Endogenous adenosine in the brain is thought to prevent the development and spread of seizures via a tonic anticonvulsant effect.”
Adenosine Kinase Elevation Increases Activity in the Kainic Acid Model of Epilepsy
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