“After 45 min ischemia followed by 60 min reperfusion of rat liver, low doses of adenosine and amrinone were administrated intraportally, resulting in significantly increased hepatic levels of cGMP, cAMP, nitrite plus nitrate in plasma, and decreased alanine aminotransferase in plasma without changing hemodynamics.”
“The present work demonstrates that combined use of low doses of adenosine and amrinone , a phosphodiesterase inhibitor, strongly inhibited reperfusion injury of the liver without eliciting hypotension.”