Possible Interaction: Adenosine and Amlodipine

“Furthermore, amlodipine increased both adenosine and NO production in the canine ischemic hearts.”

“Since amlodipine , a long-acting Ca channel blocker, increases both NO and adenosine production in canine hearts, we investigated that amlodipine activates both ecto-5(')-nucleotidase responsible for adenosine production and NO synthase (NOS) for NO production in human umbilical venous endothelial cells (HUVECs), and its cellular signaling.”

“We concluded that amlodipine activates both NOS and ecto-5(')-nucleotidase via p38MAP kinase in vitro and enhances both NO and adenosine production in vivo.”

“ Amlodipine increased the … the adenosine level (VAD (Ado): 119+/-14 to 281+/-46 nM) and the nitrate+nitrite level (VAD (NOx): 7.8+/-1.3 to 16.1+/-… muM) between coronary venous and coronary arterial blood, and also increased CBF (50+/-3 to 69+/-6 ml/100 g/min).”

“Indeed, we and others have demonstrated that: i) antagonists of either renin–… or β-adrenergic systems enhance NO-dependent pathways; ii) although carvedilol and amlodipine belong to different drug classes, … of them can increase cardiac adenosine levels; iii) increased adenosine levels by dipyridamole … associated with the improvement of CHF.”