Possible Interaction: Adenosine and Aminophylline

“Intravenous boluses of adenosine produced transient epigastric discomfort indistinguishable from spontaneous pain in five of six patients with endoscopically confirmed duodenal ulcer, an effect which was slightly but significantly antagonised by aminophylline.”

“ Aminophylline , an antagonist of the adenosine A2 receptor, had no effect on the accumulation of cyclic AMP elicited by ATP, while it inhibited the action of adenosine.”

“Finally, the effect of adenosine , but not of ATP, was inhibited by aminophylline.”

“ Aminophylline , a competitive adenosine antagonist, completely abolished this antiadrenergic effect of adenosine.”

“Adenosine antagonists aminophylline and theophylline have been utilized to reverse the effects of adenosine and may relieve adenosine-mediated adverse effects induced by ticagrelor therapy.”

“BACKGROUND: Adenosine is a soporific neuromodulator; aminophylline , which is clinically used as a bronchodilator, antagonizes the action of adenosine in the central nervous system.”

“The peak FVC responses to adenosine were not different in young (350 ± 65%) versus older adults (360 ± 80%), and aminophylline blunted these responses by ∼50% in both groups.”

“ Aminophylline antagonizes and dipyridamole potentiates the effects of adenosine.”

“ Aminophylline may antagonize the effect of adenosine and allow restoration of electrical activity, and allow ROSC.”

“ Aminophylline and salbutamol attenuated both spermine-FBS and spermine-FBS-adenosine suppression of cell survival and viability when equimolar concentration of these agents and the adenosine were applied.”