Possible Interaction: Adenosine and Alprostadil

“The combination of adenosine and 10 micrograms prostaglandin E1 was more effective in resistive index and erection grade than 20 micrograms prostaglandin E1 alone.”

“It is concluded that adenosine enhances the steroidogenic response by functional bovine luteal cells to hCG, PGE1 or PGE2 and that adenosine reduces the luteolytic response to PGF2 alpha by gonadotropin-stimulated bovine luteal cells in vitro.”

“Stimulation by adenosine was additive with the effects of GMP-P(NH)P, and alpha- or beta-adrenergic stimulation, but was abolished by prostaglandin E1 or by NaF. Prostaglandin E1 and NaF increased the sensitivity of adenylate cyclase to inhibition by adenosine.”

“ Adenosine inhibits the aggregation of human but not of rat platelets whereas both are inhibited by prostaglandin E1 or by the pyrimido‐pyrimidine compound RA233.”

“Furthermore, we now report that, whereas adenosine inhibits intracellular Ca2+ increases in platelets, it potentiates the rise in intracellular Ca2+ produced by thrombin, prostaglandin E1 , thapsigargin, and the calcium ionophore A23187 in HEL cells.”

“The ionophore A23187, PGE1 , and polystyrene beads increased the 3′,5′-adenosine monophosphate (cAMP) content of mononuclear cells and had no effect on basal cGMP content.”

“With higher adenosine concentrations, p-nitrobenzylthioguanosine was less effective in inhibiting incorporation of adenosine but blocked the decline in cyclic […. This inhibitory effect of high adenosine concentrations on the accumulation of cyclic [14C]AMP was more easily detected when adenosine … prostaglandin E1 and represents a second, … cyclic AMP levels.”

“In the present … cells; (iv) prostaglandin E1, … adenosine at pharmacological concentrations but not at physiological concentrations; (v) prostaglandin synthetase inhibitors (aspirin and indomethacin) nonspecifically inhibited the uptake of adenosine … (x) these receptor binding sites were different from the adenosine uptake protein and were competitively blocked by theophylline or aminophylline.”

“It is concluded that adenosine enhances the response of functional luteal cells to the luteotropins hCG, PGE1 or PGE2 and adenosine reduces the luteolytic response to PGF2 alpha by hCG-stimulated ovine luteal cells in vitro.”

“ADP and laser injury shortened venular haemostatic plug formation time whereas adenosine in the superfusate and PGE1 prolonged it.”