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Last Updated: 2 years ago

Possible Interaction: Adenosine and Allopurinol

supplement:

Adenosine

Research Papers that Mention the Interaction

Allopurinol increases adenosine levels in the brain, and hence is hypothesized to reduce the symptoms of mania.
Bipolar disorders  •  2014  |  View Paper
Allopurinol , a xanthine oxidase inhibitor, may increase circulating pools of adenosine and may ultimately have antipsychotic and anxiolytic effects.
The Annals of pharmacotherapy  •  2006  |  View Paper
Allopurinol (10 &mgr;M) significantly increased the level of adenosine in rat heart dialysate (n=6, p<0.05), which was inhibited by chelerythrine, 10 &mgr;M, an antagonist of protein kinase C (PKC).
In addition, allopurinol enhanced the diacylglycerol (DAG; 50 &mgr;M)‐induced also increases in adenosine production by 71.5±12.0% (n=6, P<0.05), to a level significantly (P<0.05) greater than the increase caused by DAG alone (33.0±10.6%).
In the presence of allopurinol (10 &mgr;M), a marked elevation of AMP‐primed dialysate adenosine in ischemia/reperfused rat hearts was observed.
European journal of pharmacology  •  2017  |  View Paper
Allopurinol inhibits purine degradation under severe hypoxic conditions and results in a significant increase in brain tissue levels of adenosine and inosine.
Brain Research  •  2006  |  View Paper
Two possible mechanisms were associated to the nucleoside protection: (1) the peroxide-metabolyzed enzymes, GSH-per, showed a marked increase after 30 … important role of this enzyme in the nucleoside's action; (2) the adenosine catabolism induced an increase in uric acid level, and allopurinol , a purine … of adenosine ….
Journal of biochemical toxicology  •  1995  |  View Paper
Allopurinol augmented the wash-out of adenosine and abolished that of xanthine and urate.
Journal of molecular and cellular cardiology  •  1993  |  View Paper
IMP, adenosine and AMP concentrations are increased in presence of allopurinol or oxypurinol during anoxia and reoxygenation.
Biomedica biochimica acta  •  1989  |  View Paper
The results of this study indicate that allopurinol exerts specific effects on the vasodilatory component of adenosine and prevents the adenosine-suppressive effect on the renin-angiotensin system.
The Journal of laboratory and clinical medicine  •  1986  |  View Paper
Abstract A total prevention of ethanol-induced fatty liver by the simultaneous administration of adenosine and allopurinol was observed.
Biochemical pharmacology  •  1980  |  View Paper
Allantoic acid production by the nodule cytosol fraction with inosine-5'-monophosphate , inosine, xanthosine-5'-monophosphate, xanthosine, hypoxanthine, or xanthine as substrates was NAD(+)-dependent and blocked by allopurinol.
Plant physiology  •  1980  |  View Paper