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Possible Interaction: Adenosine and Allopurinol

supplement:

Adenosine

Research Papers that Mention the Interaction

Allopurinol , a xanthine oxidase inhibitor, may increase circulating pools of adenosine and may ultimately have antipsychotic and anxiolytic effects.
The Annals of pharmacotherapy  •  2006  |  View Paper
In the lack of direct adenosine agonists, allopurinol may indirectly elevate adenosine levels by inhibiting degradation of purines.
International clinical psychopharmacology  •  2001  |  View Paper
Allantoic acid production by the nodule cytosol fraction with inosine-5'-monophosphate , inosine, xanthosine-5'-monophosphate, xanthosine, hypoxanthine, or xanthine as substrates was NAD(+)-dependent and blocked by allopurinol.
Plant physiology  •  1980  |  View Paper
Allopurinol (10μM) significantly increased the level of adenosine in rat heart dialysate (n=6, p<0.05), which was inhibited by chelerythrine, 10μM, an antagonist of protein kinase C (PKC).
In addition, allopurinol enhanced the diacylglycerol (DAG; 50μM)-induced also increases in adenosine production by 71.5±12.0% (n=6, P<0.05), to a level significantly (P<0.05) greater than the increase caused by DAG alone (33.0±10.6%).
In the presence of allopurinol (10μM), a marked elevation of AMP-primed dialysate adenosine in ischemia/reperfused rat hearts was observed.
European journal of pharmacology  •  2017  |  View Paper
Allopurinol also caused an increase in cerebrospinal fluid levels of purines, including the nucleosides adenosine and guanosine, and decreased cerebrospinal fluid concentration of uric acid.
British journal of pharmacology  •  2009  |  View Paper
Allopurinol inhibits purine degradation under severe hypoxic conditions and results in a significant increase in brain tissue levels of adenosine and inosine.
Brain Research  •  2006  |  View Paper
Two possible mechanisms were associated to the nucleoside protection: (1) the peroxide-metabolyzed enzymes, GSH-per, showed a marked increase after 30 … important role of this enzyme in the nucleoside's action; (2) the adenosine catabolism induced an increase in uric acid level, and allopurinol , a purine … of adenosine ….
Journal of biochemical toxicology  •  1995  |  View Paper
Allopurinol augmented the wash-out of adenosine and abolished that of xanthine and urate.
Journal of molecular and cellular cardiology  •  1993  |  View Paper
IMP, adenosine and AMP concentrations are increased in presence of allopurinol or oxypurinol during anoxia and reoxygenation.
Biomedica biochimica acta  •  1989  |  View Paper
The results of this study indicate that allopurinol exerts specific effects on the vasodilatory component of adenosine and prevents the adenosine-suppressive effect on the renin-angiotensin system.
The Journal of laboratory and clinical medicine  •  1986  |  View Paper
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