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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Aldesleukin
Research Papers that Mention the Interaction
“ Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively.”
Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-Activated NK cells“However, the mutated CD26 transfectants were much more sensitive to the inhibitory effect of adenosine on IL-2 production than were the wild CD26 transfectants.”
“All these factors induce CREMα overexpression, consequently result in IL-2 under-expression and IL-17A overproduction, and contribute to SLE at last.”
“Additionally, adenosine suppresses IL-2 secretion via KCa3.1 inhibition.”
“More importantly, adenosine in the absence of cell surface ADA inhibited T cell proliferation and IL-2 production induced by various stimuli.”
“In the presence of adenosine TNFα and IL2 decreased.”
Role of inflammatory cells and adenosine in lung ischemia reoxygenation injury using a model of lung donation after cardiac death“Upon costimulation with low‐dose antigen and adenosine , tyrosine phosphorylation of Grb2‐associated binder 2, which is located upstream of PI3K‐signaling, was significantly increased, but severely diminished in FcRβ‐ITAM mutant cells.”
“Thus, co-stimulation of ATP and Gi-coupled receptor agonists, such as prostaglandin E2 (PGE2) and adenosine , resulted in synergistic degranulation.”
[Elucidation of Mast Cell Activation Mechanism Mediated by Purinergic Signaling].
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