supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“We conclude that metabolic stress and AICA riboside both stimulate AMPK activity in mammalian brain, but that AICA riboside has an additional effect, i.e. competition with adenosine for uptake by the nucleoside transporter.”
AICA riboside both activates AMP‐activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus“Addition of adenosine or 2'-deoxyadenosine to nucleoside-free media also suppressed AICAR action.”
“BACKGROUND Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine and has important metabolic effects, partly through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase.”
“Some of the pharmacological properties of acadesine are attributed to it’s ability to increase local adenosine concentrations.”
“We found that acadesine also promotes adenosine release from and inhibits neutrophil adherence to connective tissue cells.”
“The purpose of this study was to determine whether acadesine increases interstitial fluid adenosine levels and attenuates myocardial stunning or potentiates the effects of adenosine in the intact pig.”
Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig.“Administration of adenosine also augmented coronary hyperemic flow and increased FS to the levels of the AICA riboside group.”
“During reperfusion, … with AICA riboside … adenosine concentration in the coronary venous blood (536+/-44 vs. 281+/-21 pmol/ml at 3 min of reperfusion, p<0.001) and … hyperemic flow (367+/-13 vs. 300+/-21 ml/100 g per min, p<0.001) when compared with the untreated group.”
“Inhibition of adhesion by adenosine was prevented by the A2 antagonist, DMPX (100 nM), and mimicked by the A2 agonist, CGS-21680 (10 nM) or the adenosine regulating agents, acadesine (100 microM) or GP531 (10 microM).”
“ Acadesine [5-amino-4-imidazolecarboxamide (AICA) riboside], a purine nucleoside analogue, increases the availability of adenosine in the tissue.”
“The enhanced adenosine caused by acadesine treatment is directly protective to cardiomyocytes, inhibits aggregation of platelets, is anti-inflammatory and enhances local blood flow by causing smooth muscle vasodilation.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback