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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acyclovir
supplement:
Polypeptides
Research Papers that Mention the Interaction
“In addition, the mean duration of lesions, number of lesions, and mean lesion area were greater in patients who lacked antibody to … lacked anti-gD; suggesting that antibody to vp66 correlated more closely with subsequent disease severity than did antibody to gD. Acyclovir therapy appears to … HSV-specific polypeptides.”
Effect of acyclovir treatment of primary genital herpes on the antibody response to herpes simplex virus.“However, after drug removal, the inhibitory effect of ACV on polypeptide synthesis was abolished in contrast to the more persistent effect of DHPG.”
“In superinfected Raji cells, ACV (100 microM) and DHPG (30 microM) inhibited synthesis of polypeptides with molecular weights of 145,000 and 140,000; in addition, synthesis of polypeptides with molecular weights of 110,000 and 85,000 was markedly reduced by DHPG but not by ACV.”
“Treatment of infected cells with acyclovir markedly affected the amounts of the four major glycosylated and certain non-glycosylated viral polypeptides synthesized; other viral polypeptides were made in normal amounts.”
Effect of Acyclovir on Viral Protein Synthesis in Cells Infected with Herpes Simplex Virus Type 1“The synthesis of six polypeptides was blocked by the most virus-specific inhibitors, acyclovir and phosphonoacetic acid.”
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