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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylglucosamine
supplement:
Serine
Research Papers that Mention the Interaction
“A very specific type of glycosylation, the addition of GlcNAc to serine or threonine (O-GlcNAc), is not only regulated by epigenetic mechanisms, but is an epigenetic modifier of histones and transcription factors.”
Epigenetic Bases of Aberrant Glycosylation in Cancer“As an illustration, we propose blocking of phosphorylation by O‐GlcNAc modification on Ser 10 , which may result in gene silencing in the presence of methylated Lys 9.”
“Intracellular attachment of O‐linked N‐acetylglucosamine to serine and threonine residues hinders phosphorylation, thereby regulating the activity of the proteins concerned.”
N‐Propanoylmannosamine interferes with O‐GlcNAc modification of the tyrosine 3‐monooxygenase and stimulates dopamine secretion“In addition to O-phosphorylation, O-linked modifications of serine and threonine by & bgr;-N-acetyl-d-glucosamine (GlcNAc) may regulate muscle contractile function.”
“O-linked attachment of GlcNAc to Ser and Thr residues regulates a variety of intracellular proteins, including transcription factors such as NFκB, c-myc, and p53.”
N-Acetylglucosamine Functions in Cell Signaling
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