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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylglucosamine
drug:
Insulin
Research Papers that Mention the Interaction
“ O‐GlcNAc regulates cellular responses to hormones such as insulin , initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription.”
O‐GlcNAc cycling: How a single sugar post‐translational modification is changing the Way We think about signaling networks“ Insulin stimulates both the biosynthesis of transcription factor Sp1 and its O-linked N-acetylglucosaminylation (O-GlcNAcylation), which promotes nuclear localization of Sp1 and its ability to transactivate calmodulin (CaM) gene transcription.”
Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1.“ Insulin increased the amount of cytosolic N - and O-linked GlcNAc by 56% from 362 +/- 30 to 564 +/- 45 dpm/microg protein .”
“ Insulin treatment of UN pups insignificantly elevated GlcNAc incorporation into the membranes.”
“Glucose, alpha-ketoisocaproate, and N-acetylglucosamine all initiate insulin release and stimulate cyclic AMP efflux and cyclic AMP accumulation.”
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