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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Acetylglucosamine and Glycine



Research Papers that Mention the Interaction

Replacement of both His(…) and Asp(232) with glycine reduced the rate of hydrolysis … the fluorogenic substrate 4'-methylumbelliferyl N-acetyl-β-D-glucosaminide 1900- and 4500-fold, respectively, and rendered activity pH-independent in the alkaline range consistent with a role of these residues in acid/base catalysis.
The Journal of biological chemistry  •  2010  |  View Paper
Substitution of glycine for tryptophan 249, whose indole ring interacts with the nonpolar B face of glucose or GlcNAc , greatly increases the K(m) for the acceptor substrate.
Glycobiology  •  2004  |  View Paper