Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Acetylglucosamine and Glycine

supplement:

Glycine

Research Papers that Mention the Interaction

Replacement of both His(…) and Asp(232) with glycine reduced the rate of hydrolysis … the fluorogenic substrate 4'-methylumbelliferyl N-acetyl-β-D-glucosaminide 1900- and 4500-fold, respectively, and rendered activity pH-independent in the alkaline range consistent with a role of these residues in acid/base catalysis.
The Journal of biological chemistry  •  2010  |  View Paper
Substitution of glycine for tryptophan 249, whose indole ring interacts with the nonpolar B face of glucose or GlcNAc , greatly increases the K(m) for the acceptor substrate.
Glycobiology  •  2004  |  View Paper