Possible Interaction: Acetylglucosamine and Glucose

“In PC-3 cells, GlcNAc supplementation also increased glucose and glutamine uptake and catabolism.”

“The pure protein has 8.0kDa (SDS-PAGE) and specifically agglutinates rabbit erythrocytes, effect that was independent of the presence of divalent cations and was inhibited after incubation with glucose and N-acetyl-d-glucosamine.”

“The most striking findings were that NAG almost completely inhibited the oxidation of glucose and sucrose by the sperm and depressed the uptake of glucose, 3‐O‐methylglucose, and sucrose.”

“Glucosamine and N-acetylglucosamine gave false positive signals when equimolar to glucose.”

“Mannose, fructose, 2-deoxyglucose and N-acetylglucosamine acted as competitive inhibitors of glucose phosphorylation and decreased the cooperativity with glucose.”

“ N-Acetylglucosamine was a competitive inhibitor with respect to glucose (Ki = 0.3 mM).”

“Both N-acetyl-D-glucosamine and N-acetyl-D-mannosamine inhibit the phosphorylation of D-glucose ; this inhibition appears to be mixed in character.”

“Gel filtration was performed also in the presence of N -acetylglucosamine , which is a competitive inhibitor and shifts to an hyperbole the saturation function for glucose.”

“In both media phosphorylation of glucose was inhibited co-operatively by N-acetylglucosamine.”

“Mannose, N-acetylglucosamine , 3-0-methylglucose, fructose, and galactose (in decreasing order of effectiveness) inhibited the uptake of glucose in a completely competitive manner; their absorptions appeared to be mediated by the glucose transport locus and, to some degree, by one or more additional transport systems.”