Possible Interaction: Acetylglucosamine and Fucose

“Here we found that bisecting GlcNAc , a branching sugar residue in N-glycan, suppresses the biosynthesis of various types of terminal epitopes in N-glycans, including fucose , sialic acid and human natural killer-1.”

“When the combined effect of Fuc and bisecting GlcNAc was examined in anti-CD20 IgG1, only a severalfold increase of ADCC was observed by the addition of GlcNAc to highly fucosylated IgG1.”

“spectroscopy, and shown to have the following structures (where AnManOH is 2,5-…-D-mannitol): [formula: see text] It is evident that the presence of fucose protects the N-acetylglucosamine residue from de-N-acetylation, and therefore fragments are produced which preserve the immediate environment of the fucose residue.”

“The presence of a fucose residue joined to C-6 of the asparagineconjugated GlcNAc residue, as well as triand tetra-antennary glycans, seems to protect the GlcNAc-asparagine linkage.”

“In this study, when L-fucose was used as radioactive precursor, the rate of L-fucose incorporation into macromolecules was markedly stimulated by addition of GlcNAc to the mutant.”

“N-acetylgalactosamine and N-acetylglucosamine inhibit to the greatest extent; galactosamine, glucosamine and fucose to a lesser extent.”

“Here we found that bisecting GlcNAc , a branching sugar residue in N-glycan, suppresses the biosynthesis of various types of terminal epitopes in N-glycans, including fucose , sialic acid and human natural killer-1.”

“In planta expression of … demonstrated that core α1,3‐fucose enhances the … of GlcNAc residues from the Fc domain of human IgG. Finally, using RNA interference, we show that suppression of HEXO3 … can be applied to increase the amounts of complex N‐glycans on plant‐produced human α1‐antitrypsin.”