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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Vorinostat
Research Papers that Mention the Interaction
“We show that Bha, Nac and Tiron markedly inhibited the cytotoxic effects of Vorinostat , increasing cell viability in vitro.”
Antioxidants Impair Anti-Tumoral Effects of Vorinostat, but Not Anti-Neoplastic Effects of Vorinostat and Caspase-8 Downregulation“ NAC decreased DNA fragmentation and caspase activity in cells treated with adaphostin and vorinostat , but not in those treated with adaphostin and entinostat.”
“While N‐acetyl cysteine NAC ) reduced ROS level and reversed the effect of SAHA on cell death, L‐buthionine sulfoximine (BSO) further enhanced GSH depletion, and promoted cell death.”
“ SAHA induced generation of reactive oxygen species (ROS), and the cleavage of HSP90 was blocked by a ROS scavenger N-acetylcystein ( NAC).”
“The well-known antioxidant N-acetyl cysteine (NAC) attenuated cell death and an increase in ROS levels was caused by SAHA.”
“The addition of either the antioxidant N-acetylcysteine or the specific inhibitor of NADPH oxidase diphenylene iodonium chloride reduced the cytotoxic effects of SAHA in HT-29 cells, suggesting that the induction of oxidative stress represents a crucial event in the apoptotic mechanism.”
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