Possible Interaction: Acetylcysteine and Vitamin K

“Moreover, the generation of reactive oxygen species (ROS) was detected in bladder cancer cells, upon treatment of vitamin K2 and the anti-oxidant N-acetyl cysteine (NAC) almost blocked the Vitamin K2-triggered apoptosis, loss of mitochondria membrane potential and activation of JNK and p38 MAPK.”

“…:N-acetylcysteine … vitamin K dependent haemostatic proteins in vivo, being maximal at one hour following the start of infusion, with maximal decreases from 1.00 to 0.….61 (0.54–0.67) for factor II, VII, IX, and X activities, protein C activity, and free protein S reactivity, respectively.”

“Addition of anti‐oxidants had different effects on the 2 inductions: N‐acetylcysteine blocked the induction of both cisplatin and menadione , whereas catalase and glutathione‐ester blocked only the menadione induction.”

“Here we show that other oxidant compounds, such as hydrogen peroxide, also induce a rapid downmodulation of membrane TfR and that pretreatment of cells with the antioxidant, thiol supplier, N-acetylcysteine inhibits the downmodulation of these receptors elicited by either menadione or hydrogen peroxide.”

“ Menadione exerted detrimental bioenergetic effects similar to those of H2O2, which were inhibited by the antioxidant N-acetylcysteine.”

“An antioxidant, N-acetylcysteine , completely inhibited the antiapoptotic effects of both menadione itself and menadione plus UVA, and peroxidation of the cells after treatment was observed using a probe to detect the intracellular production of peroxides.”

“In contrast, the oxidizing agents diamide and menadione inhibited the development of hillocks triggered by either NAC , glutathione, or prolonged culture.”

“The nucleotide depletion likely reflected the action of ROS, since the nucleotide depletion caused by TNF or oxidants such as menadione or H2O2 in cells with active c-Myc was partly inhibited by the anti-oxidant N-acetylcysteine.”