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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
Research Papers that Mention the Interaction
“Moreover, pre-treatment of transfected cells with N-acetyl L-cysteine blocked the silencing of uPA and uPAR, which further confirmed the oxidative damage-mediated downregulation.”
Radiation-inducible silencing of uPA and uPAR in vitro and in vivo in meningioma.“Treatment with NAC , an intracellular free radical scavenger, decreased the enhancement of uPA production and tumor invasion in both cells.”
“Pretreatment of the cells with N‐acetyl‐L‐cysteine (NAC) significantly prevented suppression of MMPs and uPA secretion, DNA binding activity of NF‐κB, and in vitro invasion of HT1080 cells by As2O3, suggesting a role of reactive oxygen species (ROS) in this process.”
“Treatment of … membranes with NAC significantly suppressed lipopolysaccharide-stimulated type II phospholipase A(2) release and content; PGF(2alpha), …-6, IL-8, TNFalpha, and 8-isoprostane release; and matrix metalloproteinase-9 and urokinase-type plasminogen activator enzyme activity and suppressed NF-kappaB DNA-… activity (by ANOVA, P < 0.05).”
“The combined incubation with reduced glutathione diethyl ester or N-acetylcysteine , antioxidants, suppressed the upregulation of uPA and uPAR mRNA and the increase in plasminogen activator activity by lysoPC.”
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