Possible Interaction: Acetylcysteine and Tyrosine

“This effect was also supported by the finding that treatment with N-acetylcysteine dampened the complex II stimulation, SDHA subunit tyrosine phosphorylation, and levels of antioxidant enzymes.”

“N‐acetyl‐cysteine NAC ), a general antioxidant, inhibited Cr (VI)‐induced tyrosine phosphorylation.”

“Complete inhibition of tyrosine phosphorylation was noticed when cells were stimulated in the presence of N-acetylcysteine or glutathione.”

“On the other hand, either FAK inhibitor, tyrphostin or ROS scavenger, N-acetyl-L-cysteine (NAC) suppressed the tyrosine phosphorylation and cytoskeletal changes.”

“ NAC inhibited fMLP‐induced tyrosine phosphorylation of several protein bands (42, 44, 64, and 138 kDa) in a concentration‐dependent manner.”

“ N-Acetyl-L-cysteine , a cell-permeant antioxidant, blocked the tyrosine phosphorylation of platelet substrates and also the platelet aggregation induced by H2O2 and NaVO4.”

“Furthermore, Con A-induced tyrosine phosphorylation was decreased by NAC and by AG556.”

“AGEs-stimulated Src tyrosine phosphorylation was inhibited by NAC , suggesting that Src is downstream of NAD(P)H oxidase.”

“ NAC also suppressed the NGF-induced activation of mitogen-activated protein kinases (MAPKs) and decreased the amount of tyrosine phosphorylation of MAPKs.”

“Pretreatment of vascular smooth muscle cells with the antioxidants diphenylene iodonium, Tiron, N-acetylcysteine , and ebselen significantly inhibited ( approximately 80% to 90%) tyrosine phosphorylation of the EGF-R by Ang II but not by EGF.”