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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Acetylcysteine
drug:
Trabectedin
Research Papers that Mention the Interaction
“ConclusionThis explorative study suggests that NAC can have a hepatoprotective activity in patients receiving trabectedin allowing to maintain an adequate dose intensity and continuative administration in patients with impaired liver and renal function or developing treatment-induced hepatotoxicity.”
Hepatoprotective effect of N-acetylcysteine in trabectedin-induced liver toxicity in patients with advanced soft tissue sarcoma“Here we tested the hypothesis that pretreatment of rats with modulators of hepatic drug metabolism, β-naphthoflavone, phenobarbitone or N-acetylcysteine , protect rat livers against the effects of yondelis.”
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro
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