supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
supplement:
Acetylcysteine
supplement:
Tocopherols
Research Papers that Mention the Interaction
“In conclusion, there was no treatment-related toxicity in dogs at the maximum feasible dose level by a single bolus intravenous administration while the addition of tocopherols to the liposomal formulation prolonged the circulation of NAC in plasma largely due to a decreased clearance of NAC.”
“Results from the … inclusion of tocopherols in the liposomal formulation significantly increased the … (AUC) and β-half life for NAC ; the tocopherols had greater impact on the clearance of NAC, where reductions of central compartment … 56% to 60% and reductions of tissue clearance (CL2) ranged from 73% to 77%.”
Safety and pharmacokinetic studies of liposomal antioxidant formulations containing N-acetylcysteine, α-tocopherol or γ-tocopherol in beagle dogs
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback