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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Acetylcysteine
drug:
Tigecycline
Research Papers that Mention the Interaction
“Importantly, antioxidant N-acetyl-l-cysteine (NAC) reverses the effects of tigecycline , suggesting that oxidative stress is required for the action of tigecycline in HCC cells.”
Antibiotic tigecycline enhances cisplatin activity against human hepatocellular carcinoma through inducing mitochondrial dysfunction and oxidative damage.“For biofilm-embedded bacteria, treatment with 16 mg/mL NAC alone or 2 µg/mL TGC alone resulted in … bactericidal effects (P<0.01 and P<0.05, respectively); synergistic bactericidal effect was found at 4 mg/mL NAC combined with 0.5 µg/mL TGC (P<0.01).”
“The combination of N-acetylcysteine (NAC) and tigecycline (TGC) was demonstrated to synergistically inhibit biofilm-associated bacterial infections, including methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.”
“The combination of NAC and TGC induced a partial synergistic effect (60%) and additive effect (28%) on planktonic bacteria.”
“The combination of NAC and TGC induced partial synergistic effect against planktonic cells and synergistic effect against biofilm-embedded A. baumannii, which might be a therapeutic option for biofilm-related infections of A. baumannii.”
In vitro effects of N-acetylcysteine alone and combined with tigecycline on planktonic cells and biofilms of Acinetobacter baumannii.
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