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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Thioridazine
Research Papers that Mention the Interaction
“The ROS scavenger N-acetyl cysteine (NAC) significantly attenuated hERG reduction induced by THIO and abolished the upregulation of ER stress marker proteins.”
Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation“ER stress and apoptosis caused by TDZ were prevented by ROS inhibitor N-acetyl-L-cysteine ( NAC ) and protein synthesis inhibitor cycloheximide.”
“Furthermore, thioridazine increased the production of reactive oxygen species (ROS) in Caki cells, and ROS scavengers N-acetylcysteine , glutathione ethyl ester, and trolox) inhibited thioridazine plus TRAIL-induced apoptosis, as well as Akt inhibition and the downregulation of c-FLIP(L) and Mcl-1.”
“Furthermore, thioridazine increased the production of reactive oxygen species (ROS) in Caki cells, and ROS scavengers N-acetylcysteine , glutathione ethyl ester, and trolox) inhibited thioridazine plus TRAIL-induced apoptosis, as well as Akt inhibition and the downregulation of c-FLIP(L) and Mcl-1.”
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