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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Acetylcysteine and Sulfamethoxazole

Research Papers that Mention the Interaction

The formation of these adducts with SMX was increased in the presence of ascorbic acid, whereas N-acetylcysteine decreased adduct formation with both SMX and DDS.
Journal of Pharmacology and Experimental Therapeutics  •  2005  |  View Paper
Co-incubation with glutathione or N-acetylcysteine significantly reduced the toxicity of hydroxylamine of sulfamethoxazole in HIV-infected cells (p < 0.05).
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association  •  1995  |  View Paper
The toxicity of sulfamethoxazole H/A was decreased by coincubation with glutathione or N-acetylcysteine ; there was a 47% decrease in toxicity when coincubated with 100 microM glutathione, whereas there was a 55% decrease displayed when coincubation was done with 500 microM N-acetylcysteine.
The Journal of pharmacology and experimental therapeutics  •  1988  |  View Paper