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“ N-acetyl-l-cysteine or NADPH oxidase inhibitor treatment reversed CYR61 induction by S1P , indicating that reactive oxygen species are responsible for this process.”
Arteriosclerosis, thrombosis, and vascular biology • 2011 | View Paper
“In addition, we demonstrated that the chemical antioxidant, N-acetylcysteine attenuated Raf-1 activation induced by S1P , suggesting that H(2)O(2) may be required for the signalling pathway leading to Raf-1 activation.”