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Last Updated: 2 years ago

Possible Interaction: Acetylcysteine and Sodium Bicarbonate

supplement:

Acetylcysteine

Research Papers that Mention the Interaction

In mouse … with sodium bicarbonate , which can raise the intratumoral pH. Furthermore, the protein levels of … GRP78, were also increased in response to acidic pH. The antioxidant NAC , which reduces ROS accumulation, alleviated acid-mediated ER stress and autophagy, … that autophagy was induced by acidic pH through ER stress.
Experimental cell research  •  2015  |  View Paper
Sodium bicarbonate plus N-acetylcysteine (OR 0.17, 95% CI 0.04 to 0.79; p=0.024) was better than sodium bicarbonate alone (OR 0.71, 95% CI 0.48 to 1.03; p=0.071).
BMJ Open  •  2015  |  View Paper
Combined treatment with NAC and NaHCO3 may reduce the risk of renal dysfunction after 30 days.
However, an increase in serum creatinine >25% from the baseline value to 30 day was significantly lower in patients treated with combined NAC and NaHCO3 (18.7% versus 19.1% versus 9.2% versus 21.3%; P=0.033).
Circulation. Cardiovascular interventions  •  2014  |  View Paper
N-acetylcysteine has been shown to be effective in reducing CIN incidence and in improving clinical outcomes after emergency or primary PCI, particularly when administered as a high-dose intravenous bolus or with sodium bicarbonate (4, 5).
Annals of Internal Medicine  •  2009  |  View Paper
The use of isotonic sodium bicarbonate combined with N‐acetylcysteine appears promising in providing further benefits.
Anaesthesia  •  2008  |  View Paper
However, limited data are available regarding whether sodium bicarbonate hydration, proven to be beneficial alone, can further improve outcomes when given with NAC.
The Annals of pharmacotherapy  •  2007  |  View Paper
When both the epoxide 6 and its 19-… 7 were subjected separately to a reaction with N-acetyl-L-cysteine in … of NaHCO3 , the 19-oxo compound 6 disappeared from the reaction mixture more rapidly (t1/… = 6.0 min) than the 19-methyl analog 7 (t1/2 = 16 min).
Biological & pharmaceutical bulletin  •  1997  |  View Paper
When both the epoxide 6 and its 19-… 4 were subjected separately to reaction with N-acetyl-L-cysteine in the … of NaHCO3 , the 19-oxo steroid 6 disappeared from the reaction mixture more rapidly (T1/… = 40 sec) than the 19-methyl analog 4 (T1/2 = 3.0 min).
Biochemical pharmacology  •  1996  |  View Paper
In addition NAC added as a supplement to sodium bicarbonate could increase prophylactic effects against nephropathy.
Cardiology research and practice  •  2015  |  View Paper