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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Sildenafil
Research Papers that Mention the Interaction
“Moreover, NAC combined with sildenafil inhibited the expression of MCP‐1 and p‐p38 MAPK.”
“ N‐acetylcysteine combined with sildenafil decreased MMP‐2 and MMP‐9 activity and NO consumption and inhibited apoptosis of pulmonary arterial endothelial cells.”
“ N‐acetylcysteine potentiated the haemodynamic‐improving effect of sildenafil and significantly inhibited the oxidative stress response.”
“Thus, NAC potentiates the haemodynamic‐improving effect of sildenafil in a rabbit model of acute pulmonary thromboembolism via the MCP‐1 and p38 MAPK signalling pathway.”
N‐Acetylcysteine potentiates the haemodynamic‐improving effect of sildenafil in a rabbit model of acute pulmonary thromboembolism via the p38 MAPK pathway“Furthermore, the induction of HO-1 by sildenafil was accompanied by an increase in reactive oxygen species (ROS) and blocked by N-acetyl-L-cysteine and rotenone.”
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