Possible Interaction: Acetylcysteine and Selenium

“A strong correlation was observed between the sum of the selenium and N-acetyl-cysteine concentrations, and mean sperm concentration (r = 0.67, p = 0.01), sperm motility (r = 0.64, p = 0.01) and percent normal morphology (r = 0.66, p = 0.01).”

“Administering selenium plus N-acetyl-cysteine resulted in additive beneficial effects.”

“Moreover, selenium (0.1 mg 1-1), as sodium selenite, significantly increased the protective efficiency of NAC and CIT, but not of OTC.”

“Combined treatment of lead-exposed animals with NAC and Se showed marked improvement of the biochemical, molecular, and histopathological findings.”

“The reducing agent N-acetylcysteine eliminated the effects of selenium on ERK activation, proliferation, and mobility.”

“and NAC with Se in combination.”

“The values in the hippocampus were decreased by Se and NAC administrations.”

“Our data suggest that supplementation of Se with NAC can improve the lead-induced biochemical oxidative stress in blood and tissue, the burden of lead on the body, and molecular alterations by recoupment in mean DNA damage.”

“Combined treatment of zinc and selenium with N-acetyl cysteine to dimethylmercury-exposed rats showed a substantial reduction in the levels of DMM-induced oxidative damage and comet tail length.”

“In conclusion, the results of this study support that the supplementation of zinc and selenium with N-acetyl cysteine can improve the DMM induced blood and tissue biochemical oxidative stress and molecular alterations by recoupment in mean DNA damage.”

“The study results conclude that protective intervention of combined treatment of NAC , along with Zn and Se , is beneficial in attenuating DMM-induced systemic toxicity.”

“It is concluded that protection against AAP hepatotoxicity using a combination of Se and NAC is better than that found with either agent alone.”