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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Rosiglitazone
Research Papers that Mention the Interaction
“In vitro, rosiglitazone increased the expressions of αENaC and SGK1.”
Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPARγ/SGK1 signaling pathway“Intravenous injection of 10 mg/kg RSG also caused cardiac dysfunction and oxidative stress, 600 mg/kg NAC antagonized these adverse effects.”
“… ROS significantly downregulates … AQP2 and αENaC ; however, SR1664 (a nonagonist PPARγ ligand) reduces p-PPARγ and has no effect on AQP2 and αENaC. Therefore, we conclude that in … by ROS is associated with the increases in membrane αENaC and AQP2 but has little relevance to the phosphorylation of PPARγ.”
Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression
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