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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Acetylcysteine
Research Papers that Mention the Interaction
“It is found that surfactin evoked mitochondrial ROS generation, and the surfactin-induced cell death was prevented by N-acetylcysteine ( NAC , an inhibitor of ROS).”
ROS-Ca(2+) is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis.“In this study, surfactin caused reactive oxygen species (ROS) generation and the surfactin-induced cell death was prevented by antioxidants N-acetylcysteine (NAC) and catalase, suggesting involvement of ROS generation in surfactin-induced cell death.”
“The NAC and SP600125 blocked these events induced by surfactin.”
“In conclusion, addition of NAC to surfactant treatment may enhance the therapeutic outcome in MAS.”
“This experimental study estimated whether combined use of surfactant and the antioxidant N-acetylcysteine ( NAC ) can enhance effectiveness of therapy.”
Antiinflammatory Effect of N-Acetylcysteine Combined with Exogenous Surfactant in Meconium-Induced Lung Injury.“However, the combination of NAC and surfactant facilitated rapid onset of therapeutic effect in respiratory parameters (oxygenation index, PaO(2)/FiO(2)) compared to surfactant alone and was the only treatment which prevented neutrophil migration into the lungs, oxidative damage and lung edema.”
“Moreover, NAC suppressed IL-8 and IL-beta formation and thus seems to be favorable agent for improving surfactant therapy in MAS.”
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