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Last Updated: 2 years ago

Possible Interaction: Acetylcysteine and Pulmonary Surfactants

Research Papers that Mention the Interaction

It is found that surfactin evoked mitochondrial ROS generation, and the surfactin-induced cell death was prevented by N-acetylcysteine ( NAC , an inhibitor of ROS).
Chemico-biological interactions  •  2011  |  View Paper
In this study, surfactin caused reactive oxygen species (ROS) generation and the surfactin-induced cell death was prevented by antioxidants N-acetylcysteine (NAC) and catalase, suggesting involvement of ROS generation in surfactin-induced cell death.
The NAC and SP600125 blocked these events induced by surfactin.
Chemico-biological interactions  •  2010  |  View Paper
In conclusion, addition of NAC to surfactant treatment may enhance the therapeutic outcome in MAS.
This experimental study estimated whether combined use of surfactant and the antioxidant N-acetylcysteine ( NAC ) can enhance effectiveness of therapy.
Advances in experimental medicine and biology  •  2016  |  View Paper
However, the combination of NAC and surfactant facilitated rapid onset of therapeutic effect in respiratory parameters (oxygenation index, PaO(2)/FiO(2)) compared to surfactant alone and was the only treatment which prevented neutrophil migration into the lungs, oxidative damage and lung edema.
Moreover, NAC suppressed IL-8 and IL-beta formation and thus seems to be favorable agent for improving surfactant therapy in MAS.
Physiological research  •  2014  |  View Paper