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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Acetylcysteine and Procarbazine

Research Papers that Mention the Interaction

At the highest doses of procarbazine (400 mg/kg) that caused a 56% decrease in sperm count, equimolar doses of N-acetylcysteine coadministered with procarbazine caused only a 17% decrease in sperm count, and equimolar doses of ascorbate coadministered with procarbazine caused only a 13% decrease in sperm count.
Two antioxidants, N-acetylcysteine and sodium ascorbate, administered with equimolar doses of procarbazine decreased the spermatotoxicity of procarbazine.
Cancer research  •  1987  |  View Paper