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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Probenecid
Research Papers that Mention the Interaction
“Our results indicate for the first time that NAC is substrate for OAT1 and OAT3 and that robenecid increases N AC plasma and brain exposure in vivo.”
“Time- and concentration-dependent NAC uptake that was inhibitable by probenecid was observed with OAT1 and OAT3.”
Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine“The renal accumulation of this mercapturic acid as well as its excretion into urine was inhibited by probenecid.”
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