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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Phenytoin
Research Papers that Mention the Interaction
“However, the urinary concentration of mercapturic acid was significantly higher in those given enzyme inducers, such as rifampicin or phenytoin , than in AIDS patients not treated with these drugs.”
Abnormalities in the metabolism of acetaminophen in patients infected with the human immunodeficiency virus (HIV).“Conversely, the incidence of resorptions increased when NAC was given by gavage at other times before or after phenytoin , by single or repetitive ip injections, or in high concentrations in the drinking water (P less than .05).”
“However, altering the route of NAC administration, or increasing the dose of phenytoin and/or NAC , enhanced phenytoin embryotoxicity, and NAC alone at higher doses had embryopathic effects.”
“ NAC administered in the drinking water also reduced the incidence of resorptions produced by the higher dose of phenytoin and enhanced postpartum survival in fetuses exposed to 65 or 75 mg/kg phenytoin (P less than .05).”
“Significant reductions in phenytoin-induced fetal weight loss and cleft palates were observed when NAC was given by gavage 6 hours after phenytoin or in the drinking water with the lower dose of phenytoin.”
“Thus, when given orally, NAC can partially reduce phenytoin teratogenicity and embryopathy.”
“When given with the higher dose of phenytoin, NAC administered via the drinking water significantly increased the incidence of phenytoin-induced cleft palates and fetal weight loss (P less than .05).”
Effects of N-acetylcysteine on fetal development and on phenytoin teratogenicity in mice.
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