Possible Interaction: Acetylcysteine and Phenethyl Isothiocyanate

“When oxidative stress was blocked by exposing mice to N-acetylcysteine , induction of liver UGT1A1 and CYP2B10 by PEITC was prevented.”

“The longer half-life of N-acetylcysteine conjugate of phenethyl isothiocyanate as compared to the other conjugates is consistent with its lower inhibitory activity.”

“In HCT116 cells, phenethyl isothiocyanate (PEITC) increased ROS production, which was inhibited by N-acetylcysteine (NAC) and deferoxamine (DFO) but not by ascorbic acid (ASC) and trolox (TRX) that were found to be more potent radical scavengers.”

“ PEITC lowered GSH levels, which was prevented by NAC , whereas ASC, TRX and DFO neither inhibited nor enhanced the GSH-lowering effect of PEITC.”

“The antioxidant N-acetylcysteine decreased GSK3β phosphorylation and poly(ADP-ribose) polymerase cleavage induced by 4HPR, As2O3, and PEITC , implicating oxidative stress in these effects.”

“Pretreatment with NAC blocked BITC and PEITC induced ROS elevation and NFκB inhibition.”

“Moreover, an antioxidant reagent, N-acetyl-L-cysteine (NAC) which suppresses reactive oxygen species (ROS) generation, reversed the early inhibitory effects of PEITC on cell proliferation, constitutive or IL-6-mediated JAK-STAT3 phosphorylation in PCa cells.”

“ N-acetyl-cysteine , vitamin E and z-DEVD-fmk also prevented the PEITC in inducing the loss of Deltapsim.”

“Co-treatment of PEITC and N-Acetylcysteine (a ROS scavenger) caused alterations in PEITC induced cell death and CSC markers.”

“ PEITC 's anti-cancer effect was reversed by N-acetyl-cysteine supplementation, suggesting PEITC relies on reactive oxygen species generation to induce apoptosis.”