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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Penicillins
Research Papers that Mention the Interaction
“With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased ( penicillins ) antibiotic activity.”
Effect of High N-Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens“ Acetylcysteine seems to be rapidly inactivated by high concentrations of oxygen and itself probably antagonises some penicillins and tetracyclines in sputum.2 The makers now recommend that compressed air, and not oxygen, should be used for nebulisation.”
“The presence of 10 mM NAC reduced the MIC of penicillin , ampicillin, oxacillin, cefoxitin, ceftazidime, and cefotaxime to MRSA.”
Short communication: N-Acetylcysteine-mediated augmentation of β-lactam antibacterial activity against methicillin-resistant Staphylococcus aureus isolated from bovine mastitis cases.“The presence of 10mM NAC reduced the MIC of penicillin and ampicillin but enhanced the MIC of erythromycin and ciprofloxacin for all of the strains.”
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