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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Acetylcysteine
drug:
Paclitaxel
Research Papers that Mention the Interaction
“Tumor cell death by paclitaxel was also increased by NAC treatment or the transfection with HIF-1alpha-siRNA.”
Actin-sequestering protein, thymosin beta-4, induces paclitaxel resistance through ROS/HIF-1alpha stabilization in HeLa human cervical tumor cells.“ NAC , an ROS inhibitor, inhibited cell autophagy induced by free Ptx or Ptx-NPs.”
“Conclusions: NAC alters the cytotoxicity of paclitaxel in vitro by decreasing the levels of ROS, preventing apoptosis, and modulating apoptotic cellular proteins.”
“Results: Challenge of cells with paclitaxel resulted in time/concentration-dependent decreases in cell viability and increases in intracellular levels of ROS, and apoptosis, all effects being abrogated by co-treatment with NAC.”
“Antioxidants, including N-acetylcysteine and polyethylene glycol-conjugated catalase and superoxide dismutase, inhibited the toxicity of 2DG + PTX and suppressed parameters indicative of oxidative stress in cancer cells, whereas inhibition of glutathione synthesis using BSO further sensitized breast cancer cells to 2DG + PTX.”
“Addition of N‐acetylcysteine (NAC) or glutathione, two H2O2 scavenger, induced a 4‐fold increase in paclitaxel IC50.”
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