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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Oxaliplatin
Research Papers that Mention the Interaction
“Importantly, we found that activation of the p38 and JNK signaling pathways prompted by PL and oxaliplatin was also reversed by NAC pretreatment.”
Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells“Conclusion The results of this study showed that N-acetylcysteine could reduce the incidence of the neuropathy induced by oxaliplatin and delay its occurrence in patients with gastric or colorectal cancers.”
“The effect of oxaliplatin on annexin-V-binding and forward scatter was rather augmented by removal of extracellular Ca2+, but was significantly blunted in the presence of the antioxidant N-acetyl-cysteine (1 mM).”
“We … oxaliplatin induced apoptosis, the activation of DEVDase activity, DNA fragmentation, and cleavage of PLC‐γ1 and degradation … XIAP protein in dose‐dependent manners, which was prevented by pretreatment with z‐VAD or NAC , suggesting that oxaliplatin‐induced apoptosis was mediated by …‐ or reactive oxygen species (ROS)‐dependent pathways.”
“Cisplatin and oxaliplatin were not very compatible with NAC.”
Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine - an in vitro study with pancreatic and hepatic cancer cells.
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