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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Acetylcysteine and Nitric Oxide

Research Papers that Mention the Interaction

Infusion of NAC increased the bioavailability of NO in OS, as evidenced by an increased concentration of stable metabolites of NO (NOx) in the arterial and venous circulation and in the muscle interstitium.
The Journal of physiology  •  2012  |  View Paper
NAC treatment prevented the reduction in urinary nitric oxide after angiography.
Kidney international  •  2003  |  View Paper
This effect may be mediated by an NO-dependent mechanism, probably through the protective effect of NAC on NO oxidation.
Blood pressure  •  2002  |  View Paper
However, NAC cosupplementation annulled this effect; thus, NAC may interact with nitric oxide to reduce its bioavailability.
International journal of sport nutrition and exercise metabolism  •  2018  |  View Paper
Concentrations of NAC ≥1 μM reduced the pro-oxidant response (peroxidase activity, hydrogen peroxide, malondialdehyde, nitric oxide ), and improved the anti-oxidant response (total anti-oxidant capacity, glutathione, superoxide dismutase) induced by LPS.
Respiratory Research  •  2017  |  View Paper
An NADPH oxidase inhibitor, apocynin, or antioxidant, N-acetyl-L-cysteine , substantially attenuated the reduction in both BH4 and NO.
Frontiers in bioscience  •  2011  |  View Paper
The increase of NO production by Ca2+-dependent NOS-3 expression during NAC administration reduces cell death in GCDCA-treated hepatocytes.
Toxicology and applied pharmacology  •  2010  |  View Paper
The effect of NO was also markedly reduced by the thiol-reducing agent N-acetylcysteine , suggesting a redox-dependent mechanism.
British journal of pharmacology  •  2010  |  View Paper
An approximately 2-fold increase in NO synthase-derived nitrite was observed with 10 microM NAC treatment, but the effect was not concentration dependent.
Journal of cardiovascular pharmacology  •  2009  |  View Paper
Furthermore, co-incubation with NAC allowed previously ineffective NO donors to suppress HCMC activation and thus suggested that NAC could increase the availability of NO from NO donors.
Furthermore, co-incubation with NAC allowed previously ineffective NO donors to suppress HCMC activation and thus suggested that NAC could increase the availability of NO from NO donors.
British journal of pharmacology  •  2009  |  View Paper
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