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Last Updated: 2 months ago

Possible Interaction: Acetylcysteine and Nitric Oxide

Research Papers that Mention the Interaction

NAC treatment prevented the reduction in urinary nitric oxide after angiography.
Kidney international  •  2003  |  View Paper
This effect may be mediated by an NO-dependent mechanism, probably through the protective effect of NAC on NO oxidation.
Blood pressure  •  2002  |  View Paper
N-acetyl-cysteine , a scavenger of reactive oxygen species (ROS), inhibited Cu(II)-Aβ-elicited microglial release of TNF-α and nitric oxide as well as the microglia-mediated neurotoxic effect.
Journal of Neuroinflammation  •  2015  |  View Paper
Interestingly, NAC , a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway.
Toxicology and applied pharmacology  •  2015  |  View Paper
N-acetyl-cysteine , a scavenger of reactive oxygen species (ROS), abrogated copper(II)-elicited microglial release of TNF-α and nitric oxide and subsequent neurotoxicity.
Toxicology and applied pharmacology  •  2014  |  View Paper
Co‐incubation with redox compounds, N‐acetyl‐L‐cysteine , glutathione and L‐ascorbic acid prevented NO inhibition of DNA synthesis.
British journal of pharmacology  •  2000  |  View Paper
NO production was blocked by N(G)-monomethyl-L-arginine (NMMA), an inhibitor of NO synthase (NOS), and by the antioxidant N-acetylcysteine ( NAC).
Blood  •  1997  |  View Paper
These data show that 1) the reduced thiol N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor and 2) this effect is associated with increasing intracellular platelet cyclic GMP levels.
Circulation research  •  1989  |  View Paper
However, NAC cosupplementation annulled this effect; thus, NAC may interact with nitric oxide to reduce its bioavailability.
International journal of sport nutrition and exercise metabolism  •  2018  |  View Paper
Concentrations of NAC ≥1 μM reduced the pro-oxidant response (peroxidase activity, hydrogen peroxide, malondialdehyde, nitric oxide ), and improved the anti-oxidant response (total anti-oxidant capacity, glutathione, superoxide dismutase) induced by LPS.
Respiratory Research  •  2017  |  View Paper
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