Possible Interaction: Acetylcysteine and Nitric Oxide

“ NAC treatment prevented the reduction in urinary nitric oxide after angiography.”

“This effect may be mediated by an NO-dependent mechanism, probably through the protective effect of NAC on NO oxidation.”

“ N-acetyl-cysteine , a scavenger of reactive oxygen species (ROS), inhibited Cu(II)-Aβ-elicited microglial release of TNF-α and nitric oxide as well as the microglia-mediated neurotoxic effect.”

“Interestingly, NAC , a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway.”

“ N-acetyl-cysteine , a scavenger of reactive oxygen species (ROS), abrogated copper(II)-elicited microglial release of TNF-α and nitric oxide and subsequent neurotoxicity.”

“Co‐incubation with redox compounds, N‐acetyl‐L‐cysteine , glutathione and L‐ascorbic acid prevented NO inhibition of DNA synthesis.”

“ NO production was blocked by N(G)-monomethyl-L-arginine (NMMA), an inhibitor of NO synthase (NOS), and by the antioxidant N-acetylcysteine ( NAC).”

“These data show that 1) the reduced thiol N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor and 2) this effect is associated with increasing intracellular platelet cyclic GMP levels.”

“ NAC pretreatment attenuated LPS‑induced inhibition of NO synthesis, which was consistent with the effects of SB203580.”

“The results demonstrated that NAC pretreatment alleviated LPS‑induced apoptosis and inhibition of NO production in HUVECs.”

“TNFα effect was not mediated by oxidative stress unlike NO, since the presence of N-acetyl-l-cysteine (2.5 and 5.0 mM) prevented NO induced cell cycle arrest and death.”