Possible Interaction: Acetylcysteine and Nicotine

“The effects of nicotine on pyroptotic signaling were reversed by N-acetyl-cysteine , a ROS scavenger.”

“Nicotine stimulated podocyte ROS generation; nonetheless, antioxidants such as N-acetyl cysteine NAC ) and TEMPOL (superoxide dismutase mimetic agent) inhibited this effect of nicotine.”

“In addition, perinatal nicotine treatment significantly attenuated acetylcholine-induced arterial relaxation in offspring, which was also inhibited by NAC treatment.”

“ Perinatal nicotine treatment resulted in a significant increase in arterial ROS production in offspring, which was abrogated by NAC.”

“The antioxidant compound, N-acetyl-cysteine , abrogated nicotine-activated production of reactive oxygen species and inhibited CYP1A1 expression by nicotine.”

“Furthermore, the antioxidant compound N‐acetyl‐cysteine eliminated the nicotine‐activated production of reactive oxygen species (ROS) and inhibited signal transducer and activator of transcription 3 (STAT‐3) phosphorylation; these two mechanisms mediated the upregulation of IL‐6 expression by nicotine.”

“Extracellular release of annexin A2 was also enhanced after H2O2 and nicotine treatments, which was suppressed by pretreatment with the antioxidant, N-acetyl cysteine.”

“ Nicotine increased the Bax/Bcl-2 ratio, which was attenuated by N-acetyl-L-cysteine , the NF-κB inhibitor, Bay 11–7082, and hexamethonium, a non-specific nAChR blocker.”

“N‐acetylcysteine NAC ), a promising glutamatergic therapeutic agent, has shown some clinical efficacy in reducing nicotine use in humans and has been shown to reverse drug‐induced changes in glutamatergic neurophysiology.”

“ Nicotine exposure directly inhibited Nrf2 and increased ERK phosphorylation in cardiomyocytes, which were obstructed by NAC.”

“These results suggest that NAC is inefficacious in reducing nicotine relapse in females regardless of estrous cycle phase at the dose evaluated here.”