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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Nerve Growth Factor
Research Papers that Mention the Interaction
“In analysis of "death by neglect," NAC markedly enhanced the extent of spinal ganglion neuron survival obtained with suboptimal concentrations of nerve growth factor and of oligodendrocyte survival obtained with suboptimal concentrations of CNTF or insulin-like growth factor-1.”
On the track of cell survival pharmaceuticals in the oligodendrocyte type-2 astrocyte lineage.“Moreover, blocking the oxidative activation of the protein kinase C pathway by N-acetylcysteine inhibited glucose effects on NGF synthesis.”
Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cells.“ N-acetyl-L-cysteine (NAC), which acts as a reductant in cells both by its direct reducing activity and by increasing the synthesis of the cellular antioxidant glutathione, inhibited neuronal differentiation induced by NGF or by the expression of oncogenic ras in PC12 cells.”
“In striatum and cortex, NAC prevented glial cells activation (GFAP and Iba-1), decreased NGF , Bcl-2 and NeuN, the increase of lipid peroxidation and PARP induced by GA in both ages.”
Sustained glial reactivity induced by glutaric acid may be the trigger to learning delay in early and late phases of development: Involvement of p75NTR receptor and protection by N-acetylcysteine
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