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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
Research Papers that Mention the Interaction
“The results of our study show that for MDMA intoxication the treatment with an antioxidant such as NAC may counteract the potentially hepatotoxicity.”
Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.“The antioxidant NAC significantly protected against the neurotoxic effects of MDMA metabolites.”
“Pre-treatment with the antioxidant and glutathione precursor, N-acetylcysteine (NAC), resulted in strong protection against the MDMA metabolites' neurotoxicity.”
“These data have suggested that NAC could protect against behavioral changes and apoptosis in the hippocampus following administration of MDMA.”
Attenuation of ecstasy-induced neurotoxicity by N-acetylcysteine“This data suggested a possible benefit of NAC in the treatment of neurotoxicity among those who use MDMA.”
“In contrast, all three metabolites of MDMA exhibited time- and concentration-dependent increases in ROS that were prevented by N-acetyl-cysteine (NAC).”
“Finally, thioether MDMA metabolites induced neuronal death and oxidative stress was prevented by NAC , an antioxidant and GSH precursor.”
“Addition of exogenous GSH or its precursor NAC potentiated the apoptotic action of MDMA but blocked apoptosis induced by menadione.”
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