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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Morphine
Research Papers that Mention the Interaction
“In cases that morphine increased the level of mRNAs, morphine plus NAC , result in decreased mRNA levels and vice versa.”
“The mRNA levels revealed significant differences between cells exposed to morphine and cells co-treated with morphine plus NAC.”
Down-regulation of antioxidant genes in human SH-SY5Y cells after treatment with morphine.“All of these effects of morphine could be suppressed by the JNK inhibitor SP600125 and N‐acetylcysteine.”
“ROS in turn exerted feedback regulation on JNK activation, as shown by the observations that cyclosporin A and the antioxidant N‐acetylcysteine significantly inhibited the phosphorylation of JNK induced by morphine.”
“LFP analysis revealed that morphine significantly decreased alpha (9.7-12Hz) and increased low gamma (30.3-44.9Hz) and high gamma (60.5-95.7Hz) powers in the NAc whereas M. speciosa alkaloid extract did not.”
Effects of alkaloid-rich extract from Mitragyna speciosa (Korth.) Havil. on naloxone-precipitated morphine withdrawal symptoms and local field potential in the nucleus accumbens of mice.“Reactive oxygen species (ROS) play an important role in the development of complex regional pain syndrome-Type I (…), as also demonstrated with the chronic post ischemia pain (CPIP) animal model of CRPS-I. We show that morphine and the …-acetylcysteine ( NAC ) act synergistically to reduce … allodynia in CPIP rats.”
“Furthermore, synaptophysin expression in the NAc was significantly greater after chronic administration of thienorphine, morphine , or both, than after saline.”
“Notably, Rgs9-2 in the NAc affects the analgesic actions of morphine as well as the development of analgesic tolerance.”
“These observations provide evidence that cannabinoid CB1 receptors in the NAc are involved in development of reward-related behaviors and they can potentiate the rewarding effects of morphine.”
“injection of morphine (10mg/kg) increased Arc/Arg3.1 protein levels after 2h in the NAc core but not in the NAc shell. (”
“We trust that this NAC activity could play, at least in part, a significantly role in morphine dependence and tolerance inhibition observed during the concurrent administration of morphine , NSO and NAC and thereby should be considered in data interpretation.”
“Meanwhile, morphine significantly increased dopamine level in the VTA and NAc , especially in HDC-KO mice.”
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